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KMID : 0616120070380040000
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 4 p.0 ~ p.0
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Development of Biologically Active Compounds from Edible Plant Sources-XXIV. - Anti-cancer Activity of Alcohol Extracts from Edible Plants -
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Kwak Ho-Young
Kwon Byoung-Mog
Song Myoung-Chong
Lee Jin-Hee
Yang Hye-Joung
Kim Dae-Keun
Ahn Eun-Mi
Baek Nam-In
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Abstract
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The screening of anti-cancer activity for the MeOH extracts of 163 natural sources, which were registered as edible plants by Korea Food & Drug Administration, exhibited 9 extracts to have significant inhibitory effects on farnesyl-protein transferase (FPTase) and phosphatase of regenerating liver-3 (PRL-3). In order to confirm the inhibitory activity of these active extracts, the activity assay was repeated for some fractions obtained from the active extracts using Medium Pressure Liquid Chromatography (MPLC). Some fractions of Carya illinoensis, Chlorella vulgaris, Panicum miliaceum, Perilla frutescens, Rosmarinus officinalis showed over 50% inhibitory activity on FPTase as well as those of Capsella bursa-pastoris, C. illinoensis, C. vulgaris, Coix lacrymajobi, Myristica fragrans, P. miliaceum, R. officinalis did over 50% inhibitory activity on PRL-3.
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KEYWORD
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edible plant, anti-cancer, FPTase, STAT3, PRL-3
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